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What is Anafranil? What are the uses of Anafranil?

Anafranil has a remarkable application in the management of obsessive-compulsive disorder (OCD). It helps to reduce relentless or unnecessary thoughts and it reduces the urge to carry out repeated tasks that interfere with daily living. Sometimes, it is also used in the treatment of major depressive disorder and panic attacks. Anafranil encloses a key component called Clomipramine.

What is the mode of action of Anafranil?

Clomipramine belongs to the category of tricyclic antidepressants. It exhibits its therapeutic effect by blocking norepinephrine and serotonin reuptake. This restores the balance of norepinephrine and serotonin in the brain.  Thus, it reduces depressive episodes and behaviors associated with obsessive compulsion.

What is the dosing regimen of Anafranil?

Anafranil capsule is commercially accessible in different dosing strengths of 25mg, 50mg, and 75mg. Initially, a patient has to take 25mg of Anafranil in a day at bedtime. The dose of Anafranil should be enhanced up to 100mg during the first 2 weeks of therapy. After that, the dose may be enhanced slowly over the next several weeks, up to a maximum of 250 mg per day. In order to minimize sedation, the total daily dose may be taken once a day at bedtime.

What are the contradictory conditions for the use of Anafranil?

  • Anafranil is contraindicated in patients with a history of allergic reactions with Anafranil or other tricyclic antidepressants.
  • Anafranil should not be taken in combination, or within 14 days before or after treatment, with a monoamine oxidase (MAO) inhibitor.
  • If you are recovering from a recent heart attack, then you should not use this medicine.

What are the noxious effects of Anafranil?

The common side effects are reported with the use of Anafranil such as constipation, diarrhea, lightheadedness, sleepiness, dry mouth, headache, irritability, loss of appetite, nausea, sweating, weariness, upset stomach, weakness, weight loss or gain.

What are the drugs that alter the efficacy of Anafranil?

Some medicines that affect the therapeutic efficacy of Anafranil such as Buspirone, Cimetidine, Fentanyl, Haloperidol, Lithium, Duloxetine, Chlorpromazine, Tramadol, Phenelzine, Phenobarbital, Warfarin, Clonidine, and Guanethidine.

What are the precautions to be followed during the intake of Anafranil?
  • If you are a pregnant woman, planning to become pregnant, or a lactating mother, then do not use Anafranil without consulting your doctor.
  • The use of Anafranil may cause dizziness or drowsiness, so do not drive or perform other possibly unsafe tasks after using this medicine.
  • Avoid the intake of alcoholic beverages or recreational medicines while using Anafranil.
  • Sudden discontinuation of Anafranil may cause unpleasant withdrawal symptoms, so consult a doctor how to stop using this medicine.

If you have a history of suicidal thoughts or behavior, then do not use Anafranil without consulting a doctor.

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